High -Yield Internal Medicine Board Exam Pearls by Knowmedge - HTML preview

Interactions

 Any new medication or supplement that a post-kidney transplant patient requests

should be reviewed first before prescribing

 St. John’s Wort, rifampin, phenytoin, and carbamazepine can all lower cyclosporine

levels

 Diltiazem, verapamil, and erythromycin can increase cyclosporine levels

 Cyclosporine can interfere with certain statins such as simvastatin, increasing the risk

of statin-induced rhabdomyolysis

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References:

1. Bakris GL et al. Angiotensin-Converting Enzyme Inhibitor-Associated Elevations in

Serum Creatinine: Is this a Cause for Concern? Arch Intern Med. 2000; 160 (5): 685 –

693. PMID: 10724055

2. Douglas K et al. Meta-analysis: The Effect of Statins on Albuminuria. Ann Intern Med.

2006; 145 (2): 117 – 124. PMID: 16847294

3. Levey AS et al. Definition and Classification of Chronic Kidney Disease: A Position

Statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int.

2005; 67 (6): 2089 – 2100. PMID: 15882252

4. Paige NM et al. The Top 10 Things Nephrologists Wish Every Primary Care Physician

Knew. May Clin Proc. 2009 Feb; 84 (2): 180 – 186. PMID: 19181652

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