High -Yield Internal Medicine Board Exam Pearls by Knowmedge - HTML preview

in critically ill patients

 Best predictor of efficacy of vancomycin is time above the antimicrobial MIC1

There are so many more high-yield pearls for infectious disease, but these in my humble

opinion are practice changing, cost saving, and also affect patient outcomes.

References:

1. Ackerman BH et al. Necessity of a Loading Dose When Using Vancomycin in Critically

Ill Patients. Journal of Antimicrobial Chemotherapy. 1992; 29 (4): 460 – 1. PMID:

1607335

2. Bartlett JG et al. Antibiotic-Associated Diarrhea. NEJM 2002 346: 334 – 339. PMID:

11821511

3. Fowler VG et al. Outcome of Staphylococcus Aureus Bacteremia According to

Compliance With Recommendations of Infectious Diseases Specialists: Experience

With 244 Patients. Clin Infect Dis 1998 Sep; 27 (3): 478 – 86. PMID: 9770144

4. Grace CJ et al. Usefulness of Blood Culture for Hospitalized Patients who are

Receiving Antibiotic Therapy. Clin Infect Dis 2001 Jun; 32 (11): 1651 – 5. PMID:

11340541

5. Gupta et al. International Clinical Practice Guidelines for the Treatment of Acute

Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious

Diseases Society of America and the European Society for Microbiology and Infectious

Diseases. Clin Infect Dis 2011 Mar; 52 (5): e103 – 20. PMID: 21292654

6. Hollenbach E. To Treat or Not to Treat – Critically Ill Patients with Candiduria. Mycoses

2008 Sep. 51; (2) 12 – 24. PMID: 18721329

7. Kelly CP et al. Clostridium difficile – More Difficult than Ever. NEJM 2008 Oct; 359 (18):

1932 -40. PMID: 18971494

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8. Kim AI et al. Staphylococcus Aureus Bacteremia: Using Echocardiography to Guide

Length of Therapy. Cleve Clin J Med 2003 Jun; 70 (6): 517, 520 -1, 525 -6. PMID:

12828223

9. Nguyen MH et al. Therapeutic Approaches in Patients with Candidemia. Evaluation in

a Multicenter, Prospective, Observational Study. Arch Intern Med 1995; 155 (22): 24 –

29. PMID: 7503601

10. Pappas PG et al. Clinical Practice Guidelines for the Management of Candidiasis: 2009

Update by the Infectious Diseases Society of America. Clin Infect Dis 2009 Mar; 48 (5)

503 – 35. PMID: 19191635.

11. Pien BC et al. The Clinical and Prognostic Importance of Positive Blood Cultures in

Adults. Am J Med 2010 Sep; 123 (9): 819 – 28. PMID: 20800151

12. Sharpe JN et al. Clinical And Economic Outcomes of Oral Linezolid Versus Intravenous

Vancomycin in the Treatment of MRSA-complicated, Lower-Extremity Skin and Soft-

Tissue Infections caused by Methicillin-Resistant Staphylococcus Aureus. Am J Surg

2005 Apr; 189 (4): 425 – 8. PMID: 15820454

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